Analisis Potensi Kandungan Metabolit Sekunder Biji Anggur Merah (Vitis vinifera L.) sebagai Senyawa Antikanker melalui Wnt5A Signaling Pathway secara In Silico

Yosefa Meing Siung Adjid, Irwansyah Nur Oktafian, Dwi Listyorini

Abstract


Kanker payudara adalah kanker paling umum di dunia dengan tingkat kematian tertinggi di Asia. Kanker payudara diakibatkan oleh pertumbuhan sel yang tidak terkendali yang disebabkan oleh faktor yang beragam. Meskipun pengobatan seperti kemoterapi dan radioterapi telah berkembang, penggunaan bahan alam sebagai alternatif pengobatan masih banyak digunakan. Salah satu bahan alam yang dilaporkan memiliki potensi sebagai obat antikanker adalah ekstrak biji anggur merah (Vitis vinifera L.). Penelitian ini bertujuan untuk menganalisis potensi metabolit sekunder biji anggur merah sebagai senyawa antikanker melalui Wnt5a signaling pathway secara in silico. Identifikasi senyawa dilakukan melalui studi pendahuluan, kemudian diseleksi dan dianalisis dengan uji RO5, ADME, toksisitas, efek samping, molecular docking, dan analisis HOMO-LUMO dengan software tertentu. Hasil menunjukkan bahwa Naringenin memiliki potensi sebagai senyawa antikanker dengan menghambat perkembangan kanker payudara. Penelitian lebih lanjut diperlukan untuk memvalidasi kemampuan antikanker dari senyawa Naringenin.

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